Potential of Endophytic Diaporthe sp. as a New Source of Bioactive Compounds

J Microbiol Biotechnol. 2021 Apr 28;31(4):493-500. doi: 10.4014/jmb.2005.05012.


Endophytic fungi are symbiotically related to plants and spend most of their life cycle within them. In nature, they have a crucial role in plant micro-ecosystem. They are harnessed for their bioactive compounds to counter human health problems and diseases. Endophytic Diaporthe sp. is a widely distributed fungal genus that has garnered much interest within the scientific community. A substantial number of secondary metabolites have been detected from Diaporthe sp. inhabited in various plants. As such, this minireview highlights the potential of Diaporthe sp. as a rich source of bioactive compounds by emphasizing on their diverse chemical entities and potent biological properties. The bioactive compounds produced are of significant importance to act as new lead compounds for drug discovery and development.

Keywords: Diaporthe sp.; Endophytes; Phomopsis sp.; bioactive compounds; bioactive natural products; drug discovery.

Publication types

  • Review