Dark Proteome Database: Studies on Disorder

High Throughput. 2020 Jun 30;9(3):15. doi: 10.3390/ht9030015.


There is a misconception that intrinsic disorder in proteins is equivalent to darkness. The present study aims to establish, in the scope of the Swiss-Prot and Dark Proteome databases, the relationship between disorder and darkness. Three distinct predictors were used to calculate the disorder of Swiss-Prot proteins. The analysis of the results obtained with the used predictors and visualization paradigms resulted in the same conclusion that was reached before: disorder is mostly unrelated to darkness.

Keywords: intrinsic disorder; prediction; proteins.