Application of a human T cell line derived from a Sézary syndrome patient for human interleukin 4 assay

Immunol Lett. 1988 Aug;18(4):247-53. doi: 10.1016/0165-2478(88)90170-8.


Interleukin 4 (IL-4) is a multi-functional biological regulator molecule. We developed a simple assay system for human IL-4, using a IL-2-dependent T cell line designated Sez 627 cell line. Sez 627 cells were found to respond only to human IL-4 and human IL-2, but not to other available lymphokines. In combination with mouse IL-2-dependent CTLL-2 cell line, which responds to both human and murine IL-2 but not to human IL-4, human IL-4 activity can be discriminated from human IL-2 activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Assay / methods*
  • Cell Line
  • Human T-lymphotropic virus 1
  • Humans
  • Interleukin-2 / immunology
  • Interleukin-4
  • Interleukins / analysis*
  • Interleukins / pharmacology
  • Lymphocyte Activation
  • Sezary Syndrome / immunology*
  • Species Specificity
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / microbiology


  • Interleukin-2
  • Interleukins
  • Interleukin-4