Pediatric Allergic Diseases, Food Allergy, and Oral Tolerance

Annu Rev Cell Dev Biol. 2020 Oct 6;36:511-528. doi: 10.1146/annurev-cellbio-100818-125346. Epub 2020 Jul 7.


Pediatric allergic disease is a significant health concern worldwide, and the prevalence of childhood eczema, asthma, allergic rhinitis, and food allergy continues to increase. Evidence to support specific interventions for the prevention of eczema, asthma, and allergic rhinitis is limited, and no consensus on prevention strategies has been reached. Randomized controlled trials investigating the prevention of food allergy via oral tolerance induction and the early introduction of allergenic foods have been successful in reducing peanut and egg allergy prevalence. Infant weaning guidelines in the United Sates were recently amended to actively encourage the introduction of peanut for prevention of peanut allergy.

Keywords: food allergy; oral tolerance induction; pediatric allergic disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Child
  • Food Hypersensitivity / immunology*
  • Humans
  • Immune Tolerance*
  • Immunotherapy
  • Models, Biological
  • Peanut Hypersensitivity / immunology
  • Practice Guidelines as Topic