The T-cell repertoire is heavily influenced by tolerance to polymorphic self-antigens

Nature. 1988 Oct 27;335(6193):796-801. doi: 10.1038/335796a0.


T cells with V beta 3+ alpha beta receptors are deleted by self-tolerance in mice with particular major histocompatibility complex/self-antigen combinations. This also occurs for other V beta elements. Polymorphism in the major histocompatibility complex and/or the self-antigens that cause massive deletion of T cells using particular V beta elements may be maintained by the need to balance the advantage of a diverse T-cell repertoire against the potential involvement of those elements in autoimmune disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / biosynthesis
  • Autoantigens / genetics
  • Autoantigens / immunology*
  • Chimera
  • H-2 Antigens / genetics
  • H-2 Antigens / immunology
  • Hybridomas / immunology
  • Immune Tolerance*
  • Major Histocompatibility Complex*
  • Mice
  • Mice, Inbred AKR
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred CBA
  • Polymorphism, Genetic*
  • Receptors, Antigen, T-Cell / genetics
  • Receptors, Antigen, T-Cell / immunology
  • T-Lymphocytes / immunology*


  • Antibodies, Monoclonal
  • Autoantigens
  • H-2 Antigens
  • Receptors, Antigen, T-Cell