Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion

Circ Res. 2020 Aug 28;127(6):849-850. doi: 10.1161/CIRCRESAHA.120.317025. Epub 2020 Jul 8.
No abstract available

Keywords: Cre recombinase; endothelial cell; mutation; retina; tamoxifen.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD / genetics*
  • Antigens, CD / metabolism
  • Cadherins / genetics*
  • Cadherins / metabolism
  • Gene Deletion*
  • Integrases / genetics*
  • Mice, Transgenic
  • Mutation
  • Receptors, Estrogen / drug effects*
  • Receptors, Estrogen / genetics
  • Receptors, Estrogen / metabolism
  • Retinal Neovascularization / genetics*
  • Retinal Neovascularization / metabolism
  • Retinal Neovascularization / pathology
  • Tamoxifen / pharmacology*

Substances

  • Antigens, CD
  • Cadherins
  • Receptors, Estrogen
  • cadherin 5
  • Tamoxifen
  • Cre recombinase
  • Integrases