Eburicol, lichesterol, ergosterol, and obtusifoliol from polyene antibiotic-resistant mutants of Candida albicans

Can J Microbiol. 1977 Jun;23(6):751-4. doi: 10.1139/m77-111.

Abstract

Two classes of polyene-resistant mutants were isolated from survivors of N-methyl-N'-nitro-N-nitrosoguanidine treatment of a wild-type Candida albicans. An analysis of the major sterols of one class revealed an accumulation of lichesterol and fecosterol while the other class accumulated eburicol, obtusifoliol, and lanosterol with minor quantities of C28 sterols.

Publication types

  • Comparative Study

MeSH terms

  • Amphotericin B / pharmacology
  • Candicidin / pharmacology
  • Candida albicans / analysis
  • Candida albicans / drug effects
  • Candida albicans / metabolism*
  • Cholestadienols
  • Drug Resistance, Microbial
  • Ergosterol / metabolism*
  • Lanosterol / analogs & derivatives*
  • Lanosterol / metabolism
  • Mutation
  • Natamycin / pharmacology
  • Nystatin / pharmacology
  • Phytosterols / metabolism*
  • Triterpenes / metabolism

Substances

  • Cholestadienols
  • Phytosterols
  • Triterpenes
  • Nystatin
  • Candicidin
  • Lanosterol
  • obtusifoliol
  • lichesterol
  • ebericol
  • Amphotericin B
  • Natamycin
  • Ergosterol