Outer membrane permeability and beta-lactamase content in Pseudomonas maltophilia clinical isolates and laboratory mutants

Rev Infect Dis. Jul-Aug 1988;10(4):765-9. doi: 10.1093/clinids/10.4.765.

Abstract

Low outer-membrane permeability appears to be responsible for the generally high degree of antibiotic resistance of Pseudomonas maltophilia. Constitutive overproduction of beta-lactamases affects the sensitivity of these bacteria only to those beta-lactam antibiotics that are hydrolyzed by strain-specific beta-lactamases and that do not efficiently induce these enzymes in inducible strains.

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Cell Membrane Permeability*
  • Drug Resistance, Microbial
  • Enzyme Induction
  • Hydrolysis
  • Mutation
  • Pseudomonas / drug effects
  • Pseudomonas / enzymology
  • Pseudomonas / genetics
  • Pseudomonas / metabolism*
  • beta-Lactamases / biosynthesis*
  • beta-Lactamases / metabolism
  • beta-Lactams

Substances

  • Anti-Bacterial Agents
  • beta-Lactams
  • beta-Lactamases