Small-molecule inhibitors for targeting polo-like kinase 1

Future Med Chem. 2020 Aug;12(16):1457-1460. doi: 10.4155/fmc-2020-0128. Epub 2020 Jul 8.

Authors

Iryna Kolosenko¹, Caroline Palm-Apergi¹

Affiliation

¹ Department of Laboratory Medicine, Biomolecular & Cellular Medicine, Karolinska Institutet, Stockholm, 141 57 Huddinge, Sweden.

PMID: 32638616
DOI: 10.4155/fmc-2020-0128

No abstract available

Keywords: BI2536; cancer; onvansertib; polo-like kinase 1; poloxin; small molecules; volasertib.

Publication types

Editorial

MeSH terms

Cell Cycle Proteins / antagonists & inhibitors*
Cell Cycle Proteins / metabolism
Humans
Polo-Like Kinase 1
Protein Kinase Inhibitors / chemical synthesis
Protein Kinase Inhibitors / chemistry
Protein Kinase Inhibitors / pharmacology*
Protein Serine-Threonine Kinases / antagonists & inhibitors*
Protein Serine-Threonine Kinases / metabolism
Proto-Oncogene Proteins / antagonists & inhibitors*
Proto-Oncogene Proteins / metabolism
Small Molecule Libraries / chemical synthesis
Small Molecule Libraries / chemistry
Small Molecule Libraries / pharmacology*

Substances

Cell Cycle Proteins
Protein Kinase Inhibitors
Proto-Oncogene Proteins
Small Molecule Libraries
Protein Serine-Threonine Kinases