Neurological diseases as mortality predictive factors for patients with COVID-19: a retrospective cohort study

Neurol Sci. 2020 Sep;41(9):2317-2324. doi: 10.1007/s10072-020-04541-z. Epub 2020 Jul 8.


Introduction: In the current study, we evaluated factors that increase the coronavirus disease (COVID-19) patient death rate by analyzing the data from two cohort hospitals. In addition, we studied whether underlying neurological diseases are risk factors for death.

Methods: In this retrospective cohort study, we included 103 adult inpatients (aged ≥ 18 years). We evaluated differences in demographic data between surviving and non-surviving COVID-19 patients.

Results: In a multivariate logistic analysis, age and the presence of chronic lung disease and Alzheimer's dementia (AD) were the only significant parameters for predicting COVID-19 non-survival (p < 0.05). However, hypertension, coronary vascular disease, dyslipidemia, chronic kidney disease, diabetes, and history of taking angiotensin II receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, as well as nonsteroidal anti-inflammatory drugs (NSAIDs), were not significantly associated with the death of COVID-19 patients. The optimal cutoff value obtained from the maximum Youden index was 70 (sensitivity, 80.77%; specificity, 61.04%), and the odds ratio of non-survival increased 1.055 fold for every year of age.

Conclusions: Clinicians should closely monitor and manage the symptoms of COVID-19 patients who are over the age of 70 years or have chronic lung disease or AD.

Keywords: Alzheimer’s dementia; COVID-19; Chronic lung disease; Coronavirus.

Publication types

  • Multicenter Study

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Betacoronavirus*
  • COVID-19
  • Cohort Studies
  • Coronavirus Infections / diagnosis*
  • Coronavirus Infections / mortality*
  • Female
  • Humans
  • Lung Diseases / diagnosis
  • Lung Diseases / mortality
  • Male
  • Middle Aged
  • Mortality / trends
  • Nervous System Diseases / diagnosis*
  • Nervous System Diseases / mortality*
  • Pandemics
  • Pneumonia, Viral / diagnosis*
  • Pneumonia, Viral / mortality*
  • Predictive Value of Tests
  • Republic of Korea / epidemiology
  • Retrospective Studies
  • Risk Factors
  • SARS-CoV-2