High-concentration nonavian high-molecular weight hyaluronan injections and time-to-total knee replacement surgery

J Comp Eff Res. 2020 Aug;9(11):795-805. doi: 10.2217/cer-2019-0128. Epub 2020 Jul 9.

Abstract

Aim: To examine the time-to-total knee replacement (TKR) surgery among patients with high-concentration nonavian high-molecular-weight hyaluronan injection (HMW-HA) compared with those without HA injections. Materials & methods: Using MarketScan® Commercial claims all patients aged 18-64 who underwent TKR surgery between 2008 and 2017 were identified. Time-to-TKR surgery was compared between patients receiving Orthovisc® (Anika Therapeutics Inc. Bedford MA, USA, referred to as nonavian HMW-HA) injections and patients who did not receive an HA injection. Results: The median time-to-TKR surgery was 893 days in the nonavian HMW-HA cohort and 399 days in the non-HA cohort (p < 0.001), a difference of 494 days (16.2 months). Conclusion: This study demonstrates that the time-to-TKR surgery is 16.2 months longer in patients who received treatment with nonavian HMW-HA injections.

Keywords: database; high-concentration nonavian high-molecular-weight hyaluronan; hyaluronic acid; knee osteoarthritis; retrospective; total knee replacement; viscosupplementation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / administration & dosage*
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Knee / methods*
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / therapeutic use
  • Injections, Intra-Articular
  • Middle Aged
  • Molecular Weight
  • Osteoarthritis, Knee / drug therapy*
  • Osteoarthritis, Knee / surgery*
  • Pain / drug therapy
  • Retrospective Studies
  • Time Factors
  • Treatment Outcome
  • Young Adult

Substances

  • Adjuvants, Immunologic
  • Hyaluronic Acid