Everything Illuminated-Clostridium perfringens β-toxin

Wayne I Lencer

doi:10.1016/j.chom.2020.06.006

Everything Illuminated-Clostridium perfringens β-toxin

Cell Host Microbe. 2020 Jul 8;28(1):5-6. doi: 10.1016/j.chom.2020.06.006.

Author

Wayne I Lencer¹

Affiliation

¹ Boston Children's Hospital, Boston, MA 02115, USA; Harvard Medical School, Boston, MA 02115, USA; Harvard Digestive Disease Center, Boston, MA 02115, USA. Electronic address: Wayne.Lencer@childrens.harvard.edu.

PMID: 32645353
DOI: 10.1016/j.chom.2020.06.006

Abstract

In this issue of Cell Host & Microbe, Bruggisser et al. show that Clostridium perfringens β-toxin (CPB) binds platelet endothelial cell adhesion molecule-1 (PECAM-1) (also known as CD31) to induce membrane pores. The discovery explains the cell type specificity for CPB and, in large part, the basic pathophysiology of disease.

Publication types

Comment

MeSH terms

Clostridium perfringens*
Endothelial Cells*
Platelet Endothelial Cell Adhesion Molecule-1

Substances

Platelet Endothelial Cell Adhesion Molecule-1