Centrosomal protein 55: A new paradigm in tumorigenesis

Divya Tandon; Monisha Banerjee

doi:10.1016/j.ejcb.2020.151086

Centrosomal protein 55: A new paradigm in tumorigenesis

Eur J Cell Biol. 2020 Jun;99(5):151086. doi: 10.1016/j.ejcb.2020.151086. Epub 2020 May 20.

Authors

Divya Tandon¹, Monisha Banerjee²

Affiliations

¹ Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, Uttar Pradesh 226007, India.
² Molecular and Human Genetics Laboratory, Department of Zoology, University of Lucknow, Lucknow, Uttar Pradesh 226007, India. Electronic address: monishabanerjee30@gmail.com.

PMID: 32646645
DOI: 10.1016/j.ejcb.2020.151086

Abstract

Centrosomal Protein 55 (Cep55), also known as c10orf3 and FLJ10540, was initially discovered as a major player in abscission, the final stage of cytokinesis. Subsequent studies have described its role in regulating the PI3K/AKT pathway, increasing cancer cell stemness, and promoting tumor formation. Clinically, Cep55 has been found to be overexpressed in many cancer types. Cep55 overexpression has been notably associated with tumor stage, tumor aggressiveness, poor prognosis, and metastasis. The present review discusses the role of Cep55 as a crucial biomarker and model in tumorigenesis.

Keywords: Abscission; Biomarker; Cancer; Cep55; Cytokinesis; ESCRT.

Publication types

Review

MeSH terms

Carcinogenesis
Cell Cycle Proteins / metabolism*
Cell Transformation, Neoplastic / genetics*
Humans

Substances

Cell Cycle Proteins
Cep55 protein, human