Broadly Neutralizing Antibodies to Highly Antigenically Variable Viruses as Templates for Vaccine Design

Curr Top Microbiol Immunol. 2020:428:31-87. doi: 10.1007/82_2020_221.

Abstract

Development of vaccines to highly variable viruses such as Human Immunodeficiency Virus and influenza A viruses faces multiple challenges. In this article, these challenges are described and reverse vaccinology approaches to generate universal vaccines against both pathogens are laid out and compared.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • AIDS Vaccines / chemistry
  • AIDS Vaccines / immunology*
  • Antibodies, Viral / immunology*
  • Broadly Neutralizing Antibodies / immunology*
  • HIV / chemistry
  • HIV / immunology*
  • Humans
  • Influenza Vaccines / chemistry
  • Influenza Vaccines / immunology*
  • Orthomyxoviridae / chemistry
  • Orthomyxoviridae / immunology*
  • Vaccinology*

Substances

  • AIDS Vaccines
  • Antibodies, Viral
  • Broadly Neutralizing Antibodies
  • Influenza Vaccines