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, 22 (5), 597-604

Distribution of Beta-Lactamases and Phenotype Analysis in Clinical Strains of Acinetobacter Calcoaceticus

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Distribution of Beta-Lactamases and Phenotype Analysis in Clinical Strains of Acinetobacter Calcoaceticus

M L Joly-Guillo et al. J Antimicrob Chemother.

Abstract

One hundred clinical strains of Acinetobacter calcoaceticus isolated from 1981 to 1986 were screened for enzymatic resistance to beta-lactam antibiotics. Fourteen beta-lactam antibiotics were tested and four phenotypes were defined on the basis of enzymatic resistance and of susceptibility to the following beta-lactams: ticarcillin, piperacillin, cefotaxime, and ceftazidime. The resistance of A. calcoaceticus to beta-lactam antibiotics was predominantly due to beta-lactamases, which were produced by 81% of the strains. In most (71%) of the beta-lactamase producing strains, a penicillinase of the TEM type was observed; in 9% of the strains, all isolated since 1985, a CARB-type penicillinase with a pI 6.3 was observed. The presence of a cephalosporinase type enzyme was detected in acinetobacter strains isolated since 1981 and its incidence increased in 1986. Multiple beta-lactamases (penicillinase plus cephalosporinase) were observed in 32% of the strains.

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