Large mechanical changes in the bullfrog olfactory bulb evoked by afferent fiber stimulation

Brain Res. 1988 Dec 13;475(1):173-6. doi: 10.1016/0006-8993(88)90214-4.


The isolated olfactory bulb of the bullfrog responds to olfactory nerve stimulation with large mechanical changes in the bulb. The sequence of these changes represents: (1) swelling of the bulb associated with action potential production in the secondary neurons; (2) shrinkage during powerful inhibition of the secondary neurons; and (3) swelling accompanied by repetitive firing of action potentials in the bulb. The effects of bicuculline and Cl-free Ringer on these mechanical changes were examined. The shrinkage of the bulb is closely related with the inhibitory postsynaptic potentials (IPSPs) in the mitral cells.

MeSH terms

  • Action Potentials
  • Animals
  • Electric Stimulation
  • In Vitro Techniques
  • Olfactory Bulb / physiology*
  • Olfactory Nerve / physiology*
  • Olfactory Pathways / physiology
  • Rana catesbeiana / physiology*