The Importance of Cellular Immunity in the Development of Vaccines and Therapeutics for COVID-19

J Infect Dis. 2020 Oct 1;222(9):1435-1438. doi: 10.1093/infdis/jiaa415.

Abstract

It is important to develop vaccines that can also mediate T-cell responses to SARS-CoV-2 to limit severity of infections, and to analyze the cellular immunome in the use of anti-SARS-CoV-2 therapeutics.

Keywords: COVID-19; SARS-CoV-2; T-cell immunity; human immunome; immunology; vaccines.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Aging / immunology*
  • Antigens, CD / blood
  • Betacoronavirus / immunology*
  • COVID-19
  • COVID-19 Vaccines
  • Coronavirus Infections / drug therapy
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / prevention & control
  • Drug Development
  • Flow Cytometry
  • Humans
  • Immunity, Cellular*
  • Leukocytes, Mononuclear / immunology*
  • Pandemics / prevention & control
  • Pneumonia, Viral / drug therapy
  • Pneumonia, Viral / immunology*
  • Pneumonia, Viral / prevention & control
  • SARS-CoV-2
  • Viral Vaccines*

Substances

  • Antigens, CD
  • COVID-19 Vaccines
  • Viral Vaccines