Abl1 deletion in gut stem cells suppresses p53 induction and promotes colitis-associated tumor formation

J Mol Cell Biol. 2020 Sep 1;12(9):738-740. doi: 10.1093/jmcb/mjaa022.

Authors

Guo Yu¹, Jie Fu², Ana Romo³, Baojie Li¹, Huijuan Liu¹

Affiliations

¹ Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China.
² School of Basic Medical Science, Xinxiang Medical University, Xinxiang 453003, China.
³ Laboratory of Stem Cells and Gene Therapy, Instituto Tecnológico de Chascomús (INTECH), CONICET-UNSAM, Chascomús, Buenos Aires, Argentina.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Carcinogenesis / pathology*
Colitis / pathology*
Colonic Neoplasms / pathology
Disease Models, Animal
Gastrointestinal Tract / pathology*
Gene Deletion*
Mice
Proto-Oncogene Proteins c-abl / genetics
Proto-Oncogene Proteins c-abl / metabolism*
Stem Cells / metabolism*
Tumor Suppressor Protein p53 / metabolism*

Substances

Tumor Suppressor Protein p53
Proto-Oncogene Proteins c-abl