Deep brain stimulation of the infralimbic cortex attenuates cocaine priming-induced reinstatement of drug seeking

Brain Res. 2020 Nov 1;1746:147011. doi: 10.1016/j.brainres.2020.147011. Epub 2020 Jul 8.


Deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of drug craving and addiction. To date, the nucleus accumbens has received the most attention as a potential target region for examining the impact of DBS on cocaine seeking in preclinical models. The present study investigated the effects of DBS in brain regions that send major glutamatergic projections to the nucleus accumbens including the basolateral amygdala (BLA) and ventral hippocampus (vHipp) as well as subregions of the medial prefrontal cortex (mPFC) including the anterior cingulate, infralimbic and prelimbic cortices. The current results showed that DBS in the infralimbic cortex, but not the prelimbic or anterior cingulate cortices, selectively attenuated cocaine-primed reinstatement of drug seeking in rats. The present data also demonstrated that DBS of the BLA and vHipp attenuated the reinstatement of both cocaine and sucrose seeking. These results indicate that the infralimbic cortex may be a suitable target for DBS to prevent relapse of cocaine taking.

Keywords: Anterior cingulate; Basolateral amygdala; Prefrontal cortex; Prelimbic cortex; Relapse; Ventral hippocampus.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Brain / drug effects*
  • Cocaine / pharmacology*
  • Cocaine-Related Disorders / physiopathology
  • Deep Brain Stimulation / methods*
  • Dopamine Uptake Inhibitors / pharmacology*
  • Drug-Seeking Behavior / physiology*
  • Male
  • Rats
  • Rats, Sprague-Dawley


  • Dopamine Uptake Inhibitors
  • Cocaine