Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Catherine F Houlihan; Nina Vora; Thomas Byrne; Dan Lewer; Gavin Kelly; Judith Heaney; Sonia Gandhi; Moira J Spyer; Rupert Beale; Peter Cherepanov; David Moore; Richard Gilson; Steve Gamblin; George Kassiotis; Laura E McCoy; Charles Swanton; Crick COVID-19 Consortium; Andrew Hayward; Eleni Nastouli; SAFER Investigators

doi:10.1016/S0140-6736(20)31484-7

Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers

Lancet. 2020 Jul 25;396(10246):e6-e7. doi: 10.1016/S0140-6736(20)31484-7. Epub 2020 Jul 9.

Authors

Catherine F Houlihan¹, Nina Vora², Thomas Byrne³, Dan Lewer⁴, Gavin Kelly⁵, Judith Heaney⁶, Sonia Gandhi⁷, Moira J Spyer⁶, Rupert Beale⁸, Peter Cherepanov⁹, David Moore¹⁰, Richard Gilson², Steve Gamblin⁵, George Kassiotis¹¹, Laura E McCoy¹², Charles Swanton¹³, Crick COVID-19 Consortium; Andrew Hayward⁴, Eleni Nastouli¹⁴, SAFER Investigators

Collaborators

Jim Aitken, Zoe Allen, Rachel Ambler, Karen Ambrose, Emma Ashton, Alida Avola, Samutheswari Balakrishnan, Caitlin Barns-Jenkins, Genevieve Barr, Sam Barrell, Souradeep Basu, Rupert Beale, Clare Beesley, Nisha Bhardwaj, Shahnaz Bibi, Ganka Bineva-Todd, Dhruva Biswas, Michael J Blackman, Dominique Bonnet, Faye Bowker, Malgorzata Broncel, Claire Brooks, Michael D Buck, Andrew Buckton, Timothy Budd, Alana Burrell, Louise Busby, Claudio Bussi, Simon Butterworth, Fiona Byrne, Richard Byrne, Simon Caidan, Joanna Campbell, Johnathan Canton, Ana Cardoso, Nick Carter, Luiz Carvalho, Raffaella Carzaniga, Natalie Chandler, Qu Chen, Peter Cherepanov, Laura Churchward, Graham Clark, Bobbi Clayton, Clementina Cobolli Gigli, Zena Collins, Sally Cottrell, Margaret Crawford, Laura Cubitt, Tom Cullup, Heledd Davies, Patrick Davis, Dara Davison, Annalisa D'Avola, Vicky Dearing, Solene Debaisieux, Monica Diaz-Romero, Alison Dibbs, Jessica Diring, Paul C Driscoll, Christopher Earl, Amelia Edwards, Chris Ekin, Dimitrios Evangelopoulos, Rupert Faraway, Antony Fearns, Aaron Ferron, Efthymios Fidanis, Dan Fitz, James Fleming, Bruno Frederico, Alessandra Gaiba, Anthony Gait, Steve Gamblin, Sonia Gandhi, Liam Gaul, Helen M Golding, Jacki Goldman, Robert Goldstone, Belen Gomez Dominguez, Hui Gong, Paul R Grant, Maria Greco, Mariana Grobler, Anabel Guedan, Maximiliano G Gutierrez, Fiona Hackett, Ross Hall, Steinar Halldorsson, Suzanne Harris, Sugera Hashim, Lyn Healy, Judith Heaney, Susanne Herbst, Graeme Hewitt, Theresa Higgins, Steve Hindmarsh, Rajnika Hirani, Joshua Hope, Elizabeth Horton, Beth Hoskins, Catherine F Houlihan, Michael Howell, Louise Howitt, Jacqueline Hoyle, Mint R Htun, Michael Hubank, Hector Huerga Encabo, Deborah Hughes, Jane Hughes, Almaz Huseynova, Ming-Shih Hwang, Rachael Instrell, Deborah Jackson, Mariam Jamal-Hanjani, Lucy Jenkins, Ming Jiang, Mark Johnson, Leigh Jones, Nnennaya Kanu, George Kassiotis, Louise Kiely, Anastacio King Spert Teixeira, Stuart Kirk, Svend Kjaer, Ellen Knuepfer, Nikita Komarov, Paul Kotzampaltiris, Konstantinos Kousis, Tammy Krylova, Ania Kucharska, Robyn Labrum, Catherine Lambe, Michelle Lappin, Stacey-Ann Lee, Andrew Levett, Lisa Levett, Marcel Levi, Hon-Wing Liu, Sam Loughlin, Wei-Ting Lu, James I MacRae, Akshay Madoo, Julie A Marczak, Mimmi Martensson, Thomas Martinez, Bishara Marzook, John Matthews, Joachim M Matz, Samuel McCall, Laura E McCoy, Fiona McKay, Edel C McNamara, Carlos M Minutti, Gita Mistry, Miriam Molina-Arcas, Beatriz Montaner, Kylie Montgomery, Catherine Moore, David Moore, Anastasia Moraiti, Lucia Moreira-Teixeira, Joyita Mukherjee, Cristina Naceur-Lombardelli, Eleni Nastouli, Aileen Nelson, Jerome Nicod, Luke Nightingale, Stephanie Nofal, Paul Nurse, Savita Nutan, Caroline Oedekoven, Anne O'Garra, Jean D O'Leary, Jessica Olsen, Olga O'Neill, Paula Ordonez Suarez, Nicola O'Reilly, Neil Osborne, Amar Pabari, Aleksandra Pajak, Venizelos Papayannopoulos, Namita Patel, Yogen Patel, Oana Paun, Nigel Peat, Laura Peces-Barba Castano, Ana Perez Caballero, Jimena Perez-Lloret, Magali S Perrault, Abigail Perrin, Roy Poh, Enzo Z Poirier, James M Polke, Marc Pollitt, Lucia Prieto-Godino, Alize Proust, Rajvee Shah Punatar, Clinda Puvirajasinghe, Christophe Queval, Vijaya Ramachandran, Abhinay Ramaprasad, Peter Ratcliffe, Laura Reed, Caetano Reis e Sousa, Kayleigh Richardson, Sophie Ridewood, Rowenna Roberts, Angela Rodgers, Pablo Romero Clavijo, Annachiara Rosa, Alice Rossi, Chloe Roustan, Andrew Rowan, Erik Sahai, Aaron Sait, Katarzyna Sala, Theo Sanderson, Pierre Santucci, Fatima Sardar, Adam Sateriale, Jill A Saunders, Chelsea Sawyer, Anja Schlott, Edina Schweighoffer, Sandra Segura-Bayona, Joe Shaw, Gee Yen Shin, Mariana Silva Dos Santos, Margaux Silvestre, Matthew Singer, Daniel M Snell, Ok-Ryul Song, Moira J Spyer, Louisa Steel, Amy Strange, Adrienne E Sullivan, Charles Swanton, Michele Sy Tan, Zoe H Tautz-Davis, Effie Taylor, Gunes Taylor, Harriet B Taylor, Alison Taylor-Beadling, Fernanda Teixeira Subtil, Berta Terré Torras, Patrick Toolan-Kerr, Francesca Torelli, Tea Toteva, Moritz Treeck, Hadija Trojer, Ming-Han C Tsai, James Ma Turner, Melanie Turner, Jernej Ule, Rachel Ulferts, Sharon P Vanloo, Selvaraju Veeriah, Subramanian Venkatesan, Karen Vousden, Andreas Wack, Claire Walder, Philip A Walker, Yiran Wang, Sophia Ward, Catharina Wenman, Luke Wiliams, Matthew J Williams, Wai Keong Wong, Joshua Wright, Mary Wu, Lauren Wynne, Zheng Xiang, Melvyn Yap, Julian A Zagalak, Davide Zecchin, Rachel Zillwood, Rebecca Matthews, Abigail Severn, Sajida Adam, Louise Enfield, Angela McBride, Kathleen Gärtner, Sarah Edwards, Fabiana Lorencatto, Susan Michie, Ed Manley, Maryam Shahmanesh, Hinal Lukha, Paulina Prymas, Hazel McBain, Robert Shortman, Leigh Wood, Claudia Davies, Bethany Williams, Kevin W Ng, Georgina H Cornish, Nikhil Faulkner, Andrew Riddell, Philip Hobson, Ana Agua-Doce, Kerol Bartolovic, Emma Russell, Lotte Carr, Emilie Sanchez, Daniel Frampton, Matthew Byott, Stavroula M Paraskevopoulou, Elise Crayton, Carly Meyer, Nina Vora, Triantafylia Gkouleli, Andrea Stoltenberg, Veronica Ranieri, Tom Byrne, Dan Lewer, Andrew Hayward, Richard Gilson, Gavin Kelly, Fiona Roberts, Emine Hatipoglu

Affiliations

¹ Department of Clinical Virology, University College London Hospitals, London W1T 4EU, UK; Department of Infection and Immunity, University College London, London, UK; Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK.
² Institute for Global Health, University College London, London, UK.
³ Great Ormond Street Institute of Child Health, University College London, London, UK.
⁴ Institute of Epidemiology and Healthcare, University College London, London, UK.
⁵ The Francis Crick Institute, London, UK.
⁶ Advanced Pathogen Diagnostics Unit, University College London Hospitals, London W1T 4EU, UK; Great Ormond Street Institute of Child Health, University College London, London, UK.
⁷ Queen Square Institute of Neurology, University College London, London, UK; The Francis Crick Institute, London, UK.
⁸ Division of Medicine, University College London Hospitals, London W1T 4EU, UK; The Francis Crick Institute, London, UK.
⁹ The Francis Crick Institute, London, UK; Department of Medicine, Faculty of Medicine, Imperial College London, London, UK.
¹⁰ Cancer Institute, University College London, London, UK.
¹¹ The Francis Crick Institute, London, UK; Department of Medicine, Faculty of Medicine, Imperial College London, London, UK. Electronic address: george.kassiotis@crick.ac.uk.
¹² Department of Infection and Immunity, University College London, London, UK.
¹³ Macmillan Cancer Centre, University College London Hospitals, London W1T 4EU, UK; Cancer Institute, University College London, London, UK; The Francis Crick Institute, London, UK. Electronic address: charles.swanton@crick.ac.uk.
¹⁴ Department of Clinical Virology, University College London Hospitals, London W1T 4EU, UK; Advanced Pathogen Diagnostics Unit, University College London Hospitals, London W1T 4EU, UK; Great Ormond Street Institute of Child Health, University College London, London, UK. Electronic address: e.nastouli@ucl.ac.uk.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antibodies, Viral / blood*
Betacoronavirus / immunology*
COVID-19
Coronavirus Infections / blood*
Coronavirus Infections / transmission
Cross Infection / blood*
Cross Infection / transmission
Cross Infection / virology
Health Personnel*
Humans
Infectious Disease Transmission, Patient-to-Professional
London
Occupational Exposure
Pandemics
Pneumonia, Viral / blood*
Pneumonia, Viral / transmission
Prospective Studies
Risk Assessment
SARS-CoV-2
Seroconversion*

Substances

Antibodies, Viral

Publication types

MeSH terms

Substances

Grant support