Vaccines for COVID-19: The current state of play

Archana Koirala; Ye Jin Joo; Ameneh Khatami; Clayton Chiu; Philip N Britton

doi:10.1016/j.prrv.2020.06.010

Vaccines for COVID-19: The current state of play

Paediatr Respir Rev. 2020 Sep:35:43-49. doi: 10.1016/j.prrv.2020.06.010. Epub 2020 Jun 18.

Authors

Archana Koirala¹, Ye Jin Joo², Ameneh Khatami³, Clayton Chiu⁴, Philip N Britton⁵

Affiliations

¹ National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; Department of Infectious Diseases, Nepean Hospital, Penrith, NSW, Australia. Electronic address: Archana.Koirala@health.nsw.gov.au.
² National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia. Electronic address: YeJin.Joo@health.nsw.gov.au.
³ Sydney Medical School, The University of Sydney, NSW, Australia; Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia. Electronic address: ameneh.khatami@health.nsw.gov.au.
⁴ National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; Sydney Medical School, The University of Sydney, NSW, Australia. Electronic address: clayton.chiu@health.nsw.gov.au.
⁵ Sydney Medical School, The University of Sydney, NSW, Australia; Department of Infectious Diseases and Microbiology, The Children's Hospital at Westmead, NSW, Australia. Electronic address: philip.britton@health.nsw.gov.au.

Abstract

There is a strong consensus globally that a COVID-19 vaccine is likely the most effective approach to sustainably controlling the COVID-19 pandemic. An unprecedented research effort and global coordination has resulted in a rapid development of vaccine candidates and initiation of trials. Here, we review vaccine types, and progress with 10 vaccine candidates against SARS-CoV-2 - the virus that causes COVID-19 - currently undergoing early phase human trials. We also consider the many challenges of developing and deploying a new vaccine on a global scale, and recommend caution with respect to our expectations of the timeline that may be ahead.

Keywords: Covid 19; Human trials; Timeline; Vaccines.

Publication types

Review

MeSH terms

Betacoronavirus / immunology*
COVID-19
COVID-19 Vaccines
Clinical Trials as Topic
Coronavirus Infections / immunology
Coronavirus Infections / prevention & control*
Drug Development
Humans
Middle East Respiratory Syndrome Coronavirus / immunology
Pandemics / prevention & control*
Pneumonia, Viral / prevention & control*
SARS-CoV-2
Severe acute respiratory syndrome-related coronavirus / immunology
Vaccines, DNA / immunology
Vaccines, DNA / therapeutic use*
Vaccines, Synthetic / immunology
Vaccines, Synthetic / therapeutic use*
Viral Vaccines / immunology
Viral Vaccines / therapeutic use*

Substances

COVID-19 Vaccines
Vaccines, DNA
Vaccines, Synthetic
Viral Vaccines