Genetics, Genomics, and Emergent Precision Medicine 12 Years After the Equine Reference Genome Was Published

James N MacLeod; Theodore S Kalbfleisch

doi:10.1016/j.cveq.2020.04.002

Genetics, Genomics, and Emergent Precision Medicine 12 Years After the Equine Reference Genome Was Published

Vet Clin North Am Equine Pract. 2020 Aug;36(2):173-181. doi: 10.1016/j.cveq.2020.04.002.

Authors

James N MacLeod¹, Theodore S Kalbfleisch²

Affiliations

¹ Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546-0099, USA. Electronic address: jnmacleod@uky.edu.
² Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington, KY 40546-0099, USA.

PMID: 32654780
DOI: 10.1016/j.cveq.2020.04.002

Abstract

The first equine reference genome was completed in 2007 and published in 2009. This major accomplishment has enabled equine science to advance in ways that broadly parallel the transformative impact that genomics has had on many animal species including humans. A conceptual overview of reference genomes, genome annotation, and the major implications for equine science is presented. The relationship between genomic sequencing and the accelerating application of precision P4 medicine is discussed in the context of human and equine patients. Emergent technologies built on the foundation of genomic sequencing and rapidly gaining traction in research and clinical settings are introduced.

Keywords: EquCab2; EquCab3; Equine; Genome sequencing; Genomics; Precision medicine; Reference genome.

Publication types

Review

MeSH terms

Animals
Genomics / methods
Horse Diseases / genetics*
Horse Diseases / therapy*
Horses / genetics*
Humans
Precision Medicine / veterinary*
Reference Values