Genetic defect in responsiveness to the B cell mitogen lipopolysaccharide

Eur J Immunol. 1977 May;7(5):325-8. doi: 10.1002/eji.1830070517.


Splenic B cells C57BL/10ScCr mice fail to respond to the mitogenic principle of lipopolysaccharide (LPS), and do not express a serologically defined "LPS receptor". In contrast, polyclonal B cell responses to both purified protein derivative of tuberculin and lipoprotein are conserved.

MeSH terms

  • Animals
  • Antibody Formation
  • B-Lymphocytes / immunology*
  • Cells, Cultured
  • Fluorescent Antibody Technique
  • Genes*
  • Lipopolysaccharides / pharmacology*
  • Mice
  • Mice, Inbred Strains
  • Mitogens
  • Mutation
  • Spleen / immunology


  • Lipopolysaccharides
  • Mitogens