[COVID-19 and kidney disease]

Lakartidningen. 2020 Jul 13;117:20110.
[Article in Swedish]

Abstract

Acute kidney injury (AKI), albuminuria and hematuria are common in Covid-19 and have been shown to increase mortality. Assessment with a urinary dipstick and creatinine at admission should be completed with a urinary sediment and quantification of albuminuria if positive. SARS-Cov-2 seems to enter and infect the endothelium and kidney cells, and contributes to damage in addition to hypercoagulability, multi organ failure and hyperinflammation. Underhydration and rhabdomyolysis can contribute to acute tubular necrosis. Anti-inflammatory treatment may be considered and discussed with a nephrologist. Treatment with ACEi/ARBs should be continued if possible.

Trial registration: ClinicalTrials.gov NCT04335123 NCT04311177 NCT04312009.

MeSH terms

  • Acute Kidney Injury* / virology
  • Betacoronavirus
  • COVID-19
  • Coronavirus Infections* / complications
  • Humans
  • Pandemics*
  • Pneumonia, Viral* / complications
  • SARS-CoV-2

Associated data

  • ClinicalTrials.gov/NCT04335123
  • ClinicalTrials.gov/NCT04311177
  • ClinicalTrials.gov/NCT04312009