Implications from the occurrence of Reiter's syndrome and related disorders in association with advanced HIV infection

Scand J Rheumatol Suppl. 1988;74:89-93. doi: 10.3109/03009748809102943.

Abstract

Information bearing on the prevalence and character of Reiter's syndrome and allied disorders as they occur in a setting of HIV infection was reviewed. Based on the frequency of infections by organisms capable of inducing reactive arthritis and the presence of HLA-B27 in 71% of the individuals, it was concluded that the disorder strongly resembled Reiter's syndrome occurring in the non-HIV infected group. Preliminary evidence suggested an enhanced penetrance of susceptibility among HLA-B27 individuals. In view of the preservation of CD8 lineage T cells and functional loss of CD4 lineage T cells in HIV-infected patients, it was suggested that a specific immune recognition event is at the center of the pathogenesis of this syndrome which involves preservation of an unknown antigen in the context of HLA-B27 to CD8 lineage suppressor/cytotoxic T cells.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / immunology*
  • Arthritis / immunology
  • Arthritis, Reactive / complications
  • Arthritis, Reactive / immunology*
  • Disease Susceptibility
  • HLA-B Antigens
  • HLA-B27 Antigen
  • Humans
  • Psoriasis / immunology

Substances

  • HLA-B Antigens
  • HLA-B27 Antigen