The effect of astaxanthin supplementation on performance and fat oxidation during a 40 km cycling time trial

J Sci Med Sport. 2021 Jan;24(1):92-97. doi: 10.1016/j.jsams.2020.06.017. Epub 2020 Jul 3.

Abstract

Objectives: This study aimed to investigate whether supplementation with 12 mg⋅day-1 astaxanthin for 7 days can improve exercise performance and metabolism during a 40 km cycling time trial.

Design: A randomised, double-blind, crossover design was employed.

Methods: Twelve recreationally trained male cyclists (VO2peak: 56.5 ± 5.5 mL⋅kg-1⋅min-1, Wmax: 346.8 ± 38.4 W) were recruited. Prior to each experimental trial, participants were supplemented with either 12 mg⋅day-1 astaxanthin or an appearance-matched placebo for 7 days (separated by 14 days of washout). On day 7 of supplementation, participants completed a 40 km cycling time trial on a cycle ergometer, with indices of exercise metabolism measured throughout.

Results: Time to complete the 40 km cycling time trial was improved by 1.2 ± 1.7% following astaxanthin supplementation, from 70.76 ± 3.93 min in the placebo condition to 69.90 ± 3.78 min in the astaxanthin condition (mean improvement = 51 ± 71 s, p = 0.029, g = 0.21). Whole-body fat oxidation rates were also greater (+0.09 ± 0.13 g⋅min-1, p = 0.044, g = 0.52), and the respiratory exchange ratio lower (-0.03 ± 0.04, p = 0.024, g = 0.60) between 39-40 km in the astaxanthin condition.

Conclusions: Supplementation with 12 mg⋅day-1 astaxanthin for 7 days provided an ergogenic benefit to 40 km cycling time trial performance in recreationally trained male cyclists and enhanced whole-body fat oxidation rates in the final stages of this endurance-type performance event.

Keywords: Antioxidants; Dietary supplements; Nutrition; Sports; Sports performance; Substrate utilisation.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adipose Tissue / metabolism*
  • Adult
  • Bicycling / physiology*
  • Confidence Intervals
  • Cross-Over Studies
  • Double-Blind Method
  • Fibrinolytic Agents / administration & dosage
  • Fibrinolytic Agents / pharmacology*
  • Humans
  • Male
  • Oxidation-Reduction / drug effects
  • Performance-Enhancing Substances / administration & dosage
  • Performance-Enhancing Substances / pharmacology*
  • Recreation
  • Sports Nutritional Physiological Phenomena / drug effects
  • Time Factors
  • Xanthophylls / administration & dosage
  • Xanthophylls / pharmacology

Substances

  • Fibrinolytic Agents
  • Performance-Enhancing Substances
  • Xanthophylls
  • astaxanthine