Control of allosteric electrochemical protein switch using magnetic signals

Chem Commun (Camb). 2020 Aug 11;56(64):9206-9209. doi: 10.1039/d0cc04284f.

Abstract

We report a novel approach for magneto-controlled activation of an artificial electro-enzymatic cascade. The input signal triggers release of a caged ligand peptide, its proteolytic processing and activation of an artificial allosteric enzyme based on PQQ-dependent glucose dehydrogenase. The developed cascade was used to assemble a magneto-controlled biofuel cell.

MeSH terms

  • Alanine Transaminase / chemistry
  • Allosteric Regulation
  • Amino Acid Oxidoreductases / chemistry
  • Bioelectric Energy Sources*
  • Calmodulin / chemistry*
  • Calmodulin-Binding Proteins / chemistry*
  • Electrochemical Techniques / instrumentation
  • Electrochemical Techniques / methods
  • Electrodes
  • Enzymes, Immobilized / chemistry
  • Glucose / chemistry
  • Glucose Dehydrogenases / chemistry*
  • Magnetic Fields
  • Magnetite Nanoparticles / chemistry*
  • Nanotubes, Carbon / chemistry
  • Oxidoreductases Acting on CH-CH Group Donors / chemistry
  • Recombinant Fusion Proteins / chemistry

Substances

  • Calmodulin
  • Calmodulin-Binding Proteins
  • Enzymes, Immobilized
  • Magnetite Nanoparticles
  • Nanotubes, Carbon
  • Recombinant Fusion Proteins
  • Glucose Dehydrogenases
  • glucose dehydrogenase (pyrroloquinoline-quinone)
  • Oxidoreductases Acting on CH-CH Group Donors
  • bilirubin oxidase
  • Amino Acid Oxidoreductases
  • L-glutamate oxidase
  • Alanine Transaminase
  • Glucose