In vivo effect of 1 alpha-hydroxyvitamin D3 on interleukin-2 production in hemodialysis patients

Nephron. 1988;50(4):295-8. doi: 10.1159/000185191.

Abstract

The immunoregulatory effect of 1 alpha-OHD3, a precursor form of active vitamin D3 1,25 (OH)2D3, was examined in hemodialysis patients. Peripheral blood mononuclear cells (PBM) from hemodialysis patients produced significantly less interleukin-2 (IL-2) than those from normal controls. Four weeks of oral administration of 0.5 micrograms/day of 1 alpha-OHD3 enhanced the IL-2 production of PBM from the patients. This fact suggests that 1 alpha-OHD3 therapy may be useful for the restoration of IL-2 production in hemodialysis patients, and that the vitamin D3 deficiency may be responsible for the impairment of cellular immunity associated with IL-2 production disorder in hemodialysis patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Calcitriol / blood
  • Calcium / blood
  • Cells, Cultured
  • Humans
  • Hydroxycholecalciferols / pharmacology*
  • Interleukin-2 / biosynthesis
  • Interleukin-2 / blood*
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / immunology
  • Kidney Failure, Chronic / therapy
  • Middle Aged
  • Monocytes / drug effects
  • Monocytes / immunology*
  • Parathyroid Hormone / blood
  • Phosphates / blood
  • Renal Dialysis*

Substances

  • Hydroxycholecalciferols
  • Interleukin-2
  • Parathyroid Hormone
  • Phosphates
  • Calcitriol
  • Calcium
  • alfacalcidol