COVID-19-associated coagulopathy-Hypothesis: Are children protected due to enhanced thrombin inhibition by higher α 2 -Macroglobulin macroglobulin (α2-M)?

J Thromb Haemost. 2020 Sep;18(9):2416-2418. doi: 10.1111/jth.15013.

Abstract

We are overwhelmed by scientific publications on clinical observations, virology and epidemiology of SARS‐CoV‐2 infections. There is a growing body of evidence that hypercoagulability complicates COVID‐19, probably contributing to poor prognosis.

Publication types

  • Letter

MeSH terms

  • Adult
  • Anticoagulants
  • Antithrombins / blood
  • Blood Coagulation
  • Blood Coagulation Disorders / complications*
  • COVID-19 / complications*
  • COVID-19 / immunology
  • Child
  • Endothelial Cells / metabolism
  • Family Health
  • Hemorrhage
  • Humans
  • Male
  • Models, Theoretical
  • Phenotype
  • Pregnancy-Associated alpha 2-Macroglobulins / metabolism*
  • Pulmonary Embolism / complications
  • Thrombin / antagonists & inhibitors*
  • Venous Thrombosis / complications

Substances

  • Anticoagulants
  • Antithrombins
  • Pregnancy-Associated alpha 2-Macroglobulins
  • Thrombin