Development of Bioreduction Labile Protecting Groups for the 2'-Hydroxyl Group of RNA

Org Lett. 2020 Aug 7;22(15):6006-6009. doi: 10.1021/acs.orglett.0c02086. Epub 2020 Jul 14.


Protection and deprotection of the 2'-hydroxyl group of RNAs are critical for RNA-based drug discovery. This paper reports development of a bioreduction labile protecting group of the 2'-hydroxyl group in RNA. After the reduction of the nitro group in a chemical or enzymatic manner, the protecting groups were removed spontaneously. The attachment of electron-donating groups to the benzene ring or benzylic carbon enabled fast and controllable deprotection of the 2'-hydroxyl protecting group under physiological conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Hydroxyl Radical
  • Molecular Structure
  • RNA*


  • Hydroxyl Radical
  • RNA