Good Guy in Bad Company: How STRNs Convert PP2A into an Oncoprotein

Cancer Cell. 2020 Jul 13;38(1):20-22. doi: 10.1016/j.ccell.2020.06.011.


Certain Protein Phosphatase 2A (PP2A) complexes are human tumor suppressors. In contrast, a paper in this issue of Cancer Cell and two other recent studies demonstrate that PP2A-STRN3/4 complexes inactivate Hippo tumor suppressor pathway, resulting in YAP activation and tumorigenesis. Furthermore, this new oncogenic phosphatase mechanism may be druggable.