Alpha 1 antitrypsin deficiency in two population groups in north Italy

Padiatr Padol. 1988;23(4):307-11.


We determined the PiM, PiS and PiZ gene frequencies by isoelectric focusing in 9128 newborns from two major ethnic groups, an Italian and a German one, in the Northern part of Italy. In the Italian group the PiS allele frequency is 0.032, the PiZ = 0.015, in the German one 0.015 and 0.019 respectively. Nine ZZ, 2 SS, 10 SZ, 314 MZ and 307 MS were detected. In our two population groups the PiS reflects better than other alleles a close genetic relationship between our German population and studied groups in Austria and Germany.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Gene Frequency
  • Genetics, Population*
  • Humans
  • Infant, Newborn
  • Italy
  • Phenotype
  • alpha 1-Antitrypsin / genetics*


  • alpha 1-Antitrypsin