[Changes in the bioelectrochemical activity of the neurosecretory hypothalamic nuclei in fever caused by endogenous pyrogen/interleukin-1]

Fiziol Zh SSSR Im I M Sechenova. 1988 Dec;74(12):1731-7.
[Article in Russian]


Bioelectrochemical potentials of the rabbit hypothalamic supraoptic, paraventricular, suprachiasmatic nuclei, and medial preoptic area changed in a similar way in fever induced with i.v. administration of leucocytic pyrogen/interleukin I in all the structures due, probably, to their compact localization. The dynamics of bioelectrochemical activity coincided with that of rectal temperature derivative. The alterations of bioelectrochemical activity seem to reflect hypothalamic metabolic changes closely associated with effector mechanisms of thermoregulation in fever rather than with the temperature itself. The differences in the reaction patterns of neurosecretory nuclei are compared with changes in their vasopressin-synthetizing function during fever.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Body Temperature / drug effects
  • Body Temperature Regulation / drug effects
  • Fever / chemically induced
  • Fever / physiopathology*
  • Hypothalamus / physiopathology*
  • Interleukin-1 / pharmacology*
  • Male
  • Membrane Potentials / drug effects
  • Neurosecretory Systems / physiopathology*
  • Pyrogens / pharmacology*
  • Rabbits
  • Rectum
  • Vasopressins / biosynthesis


  • Interleukin-1
  • Pyrogens
  • Vasopressins