Whole-exome and HLA sequencing in Febrile infection-related epilepsy syndrome

Ann Clin Transl Neurol. 2020 Aug;7(8):1429-1435. doi: 10.1002/acn3.51062. Epub 2020 Jul 14.

Abstract

Febrile infection-related epilepsy syndrome (FIRES) is a devastating epilepsy characterized by new-onset refractory status epilepticus with a prior febrile infection. We performed exome sequencing in 50 individuals with FIRES, including 27 patient-parent trios and 23 single probands, none of whom had pathogenic variants in established genes for epilepsies or neurodevelopmental disorders. We also performed HLA sequencing in 29 individuals with FIRES and 529 controls, which failed to identify prominent HLA alleles. The genetic architecture of FIRES is substantially different from other developmental and epileptic encephalopathies, and the underlying etiology remains elusive, requiring novel approaches to identify the underlying causative factors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Communicable Diseases / complications*
  • Drug Resistant Epilepsy / etiology
  • Drug Resistant Epilepsy / genetics
  • Epileptic Syndromes / etiology*
  • Epileptic Syndromes / genetics*
  • Female
  • Fever / complications*
  • HLA Antigens / genetics*
  • Humans
  • Male
  • Sequence Analysis, DNA*
  • Status Epilepticus / etiology
  • Status Epilepticus / genetics
  • Whole Exome Sequencing

Substances

  • HLA Antigens