Anti-inflammatory and peripheral analgesic activity of esculetin in vivo

A Tubaro; P Del Negro; E Ragazzi; S Zampiron; R Della Loggia

doi:10.1016/s0031-6989(88)80847-6

Anti-inflammatory and peripheral analgesic activity of esculetin in vivo

Pharmacol Res Commun. 1988 Dec:20 Suppl 5:83-5. doi: 10.1016/s0031-6989(88)80847-6.

Authors

A Tubaro¹, P Del Negro, E Ragazzi, S Zampiron, R Della Loggia

Affiliation

¹ Institute of Pharmacology and Pharmacognosy, University of Trieste, Italy.

PMID: 3266797
DOI: 10.1016/s0031-6989(88)80847-6

Abstract

Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.

MeSH terms

Acetylcholine / toxicity
Animals
Anti-Inflammatory Agents, Non-Steroidal* / toxicity
Croton Oil / toxicity
Drug Evaluation, Preclinical
Edema / drug therapy
Male
Mice
Mice, Inbred Strains
Peroxidases / metabolism
Umbelliferones / pharmacology*
Umbelliferones / toxicity

Substances

Anti-Inflammatory Agents, Non-Steroidal
Umbelliferones
Croton Oil
Peroxidases
Acetylcholine
esculetin