Anti-inflammatory and peripheral analgesic activity of esculetin in vivo

Pharmacol Res Commun. 1988 Dec;20 Suppl 5:83-5. doi: 10.1016/s0031-6989(88)80847-6.

Abstract

Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.

MeSH terms

  • Acetylcholine / toxicity
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal* / toxicity
  • Croton Oil / toxicity
  • Drug Evaluation, Preclinical
  • Edema / drug therapy
  • Male
  • Mice
  • Mice, Inbred Strains
  • Peroxidases / metabolism
  • Umbelliferones / pharmacology*
  • Umbelliferones / toxicity

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Umbelliferones
  • Croton Oil
  • Peroxidases
  • Acetylcholine
  • esculetin