Cronkhite-Canada Syndrome Associated with Gastric Outlet Obstruction and Membranous Nephropathy: A Case Report and Review of the Literature

Intern Med. 2020 Nov 15;59(22):2871-2877. doi: 10.2169/internalmedicine.5278-20. Epub 2020 Jul 14.

Abstract

A 47-year-old man presented with dysgeusia, anorexia, and diarrhea. An endoscopic evaluation showed widespread gastrointestinal nodular inflammation and polyps. The pathological findings were consistent with Cronkhite-Canada Syndrome (CCS). Prednisolone therapy resulted in clinical improvement. However, CCS relapse complicated with gastric obstruction was observed during drug tapering. Although his symptoms disappeared after the reintroduction of steroids, he developed membranous nephritis. Additional cyclosporine A (CyA) treatment dramatically improved his proteinuria and residual gastrointestinal polyposis. The clinical symptoms resolved with steroid treatment, while CyA was effective for both CCS lesions and membranous nephropathy. CyA might therefore be a potential treatment option for CCS associated with membranous nephropathy.

Keywords: cyclosporine; gastric obstruction; membranous glomerulonephritis; prednisolone.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Gastric Outlet Obstruction*
  • Glomerulonephritis, Membranous* / complications
  • Glomerulonephritis, Membranous* / diagnosis
  • Glomerulonephritis, Membranous* / drug therapy
  • Humans
  • Intestinal Polyposis* / complications
  • Intestinal Polyposis* / diagnosis
  • Intestinal Polyposis* / drug therapy
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Prednisolone / therapeutic use

Substances

  • Prednisolone