Immune mediated necrotizing myopathy: A rare complication of statin therapy

Clin Pract. 2020 Jun 30;10(2):1248. doi: 10.4081/cp.2020.1248. eCollection 2020 May 19.


Immune mediated necrotizing myopathy (IMNM) is part of the inflammatory myopathies group of diseases and presents with muscle weakness, myalgias and elevated serum creatine phosphokinase (CPK). Statin-induced IMNM is a rare complication. We present a patient with IMNM secondary to simvastatin use. The patient presented with proximal myopathy, dysphagia, and elevated creatinine kinase levels, and was subsequently found to have anti-3- hydroxy-3-methylglutaryl-CoA reductase (HMGCR) autoantibodies with a necrotizing process on muscle biopsy. This patient's case was further complicated by sequelae of multiple disease processes, ultimately leading to deterioration of his health.

Keywords: Immune mediated necrotizing myopathy; inflammatory myopathy; statin-induced IMNM; statins.