Autophagy and Alzheimer's Disease

Adv Exp Med Biol. 2020;1207:3-19. doi: 10.1007/978-981-15-4272-5_1.


Alzheimer's disease (AD) is the most common type of dementia and is characterized by progressive cognitive decline. Increasing evidence has demonstrated that the autophagic process plays an important role in AD. In this chapter, we will discuss the role of autophagy in the pathogenesis of AD and other types of dementia, including dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), vascular dementia (VD) and prion diseases. In addition, we will discuss autophagy-targeted therapies as future treatments for AD.

Keywords: Alzheimer’s disease; Autophagy; Dementia.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease*
  • Autophagy*
  • Dementia, Vascular
  • Frontotemporal Dementia
  • Humans
  • Lewy Body Disease