Autophagy and Epilepsy

Adv Exp Med Biol. 2020;1207:163-169. doi: 10.1007/978-981-15-4272-5_10.


Epilepsy is a long-term neurological disease characterized by convulsions that can be recurrent. It is mainly caused by an imbalance between excitation and inhibition in the central nervous system. Currently, the pathogenesis is still unclear, although it may be related to changes in ion channels, neurotransmitters and glial cells. In recent years, increasing attention has been paid to the role of autophagy in the development of epilepsy. This chapter focuses on the role of the mTOR pathway in epileptogenesis and the relationship between autophagy, glycogen metabolism and Lafora disease and discusses the potential role of autophagy as a target for the treatment of epilepsy.

Keywords: Autophagy; Epilepsy; mTOR.

Publication types

  • Review

MeSH terms

  • Autophagy* / drug effects
  • Epilepsy* / therapy
  • Humans
  • Lafora Disease
  • Seizures