Autophagy and Bacterial Infection

Adv Exp Med Biol. 2020;1207:413-423. doi: 10.1007/978-981-15-4272-5_29.


Bacterial infection is a common clinical disease that can affect a variety of organs and tissues. Autophagy, as an important part of the innate immune response and adaptive immune response, plays an important role in the defense against bacterial infection. Bacteria can also evade autophagy by destroying or utilizing autophagy virulence proteins or related molecules. Studying the mechanism of autophagy in bacteria and its interaction with cells help to discover new pathogenic mechanisms of bacterial infection. This chapter introduces the possible mechanisms of autophagy during bacterial infections such as Salmonella and Mycobacterium tuberculosis, in order to discover new ways to prevent and control infectious diseases.

Keywords: Autophagy; Bacterial infection; Immune; Interaction.

Publication types

  • Review

MeSH terms

  • Autophagy* / immunology
  • Bacterial Infections* / immunology
  • Bacterial Infections* / microbiology
  • Humans
  • Mycobacterium tuberculosis / immunology
  • Mycobacterium tuberculosis / pathogenicity
  • Salmonella / immunology
  • Salmonella / pathogenicity
  • Virulence