Molecules derived from the extremes of life: a decade later

Nat Prod Rep. 2021 Jan 1;38(1):24-82. doi: 10.1039/d0np00021c. Epub 2020 Jul 16.

Abstract

Covering: Early 2008 until the end of 2019Microorganisms which survive (extreme-tolerant) or even prefer (extremophilic) living at the limits of pH, temperature, salinity and pressure found on earth have proven to be a rich source of novel structures. In this update we summarise the wide variety of new molecules which have been isolated from extremophilic and extreme-tolerant microorganisms since our original 2009 review, highlighting the range of bioactivities these molecules have been reported to possess.

Publication types

  • Review

MeSH terms

  • Alkaloids / chemistry
  • Alkaloids / pharmacology
  • Bacteria* / classification
  • Bacterial Physiological Phenomena
  • Biological Products / chemistry*
  • Biological Products / metabolism
  • Biological Products / pharmacology*
  • Extreme Environments*
  • Fungi* / classification
  • Fungi* / physiology
  • Humans
  • Hydrogen-Ion Concentration
  • Molecular Structure
  • Peptides / chemistry
  • Peptides / pharmacology
  • Polyketides / chemistry
  • Polyketides / pharmacology
  • Temperature
  • Terpenes / chemistry
  • Terpenes / pharmacology

Substances

  • Alkaloids
  • Biological Products
  • Peptides
  • Polyketides
  • Terpenes