Rhegmatogenous Retinal Detachment after Intravitreal Injection

Ophthalmol Retina. 2021 Feb;5(2):178-183. doi: 10.1016/j.oret.2020.07.007. Epub 2020 Jul 14.


Purpose: To describe the clinical features and outcomes in patients with rhegmatogenous retinal detachment (RRD) after intravitreal injection of pharmacologic agents.

Design: Retrospecitve case series.

Participants: Patients diagnosed with rhegmatogenous retinal detachment within 3 months of receiving an intravitreal injection of a pharmacologic agent for treatment of macular disease.

Methods: Retrospective case series of reported cases of RRD in patients with prior intravitreal injection who underwent subsequent surgical repair at a university referral center.

Main outcome measures: Visual acuity (VA), single surgery anatomic success rate (SSAS) and retinal reattachment at last follow-up.

Results: Thirteen patients were identified to have RRD within 3 months of intravitreal injection. Injection was performed in the inferotemporal quadrant in 12 of 13 eyes (92%) with a 31- or 32-gauge needle. Additional risk factors for RRD other than intravitreal injection were present in 5 of 13 eyes (38%), including prior pars plana vitrectomy (3 eyes), history of retinal tear (1 eye), and history of RRD in the fellow eye (1 eye). Average duration from time of injection to diagnosis of RRD was 27 days (range, 5-43 days). Retinal reattachment was achieved in 12 of 13 eyes (92%). Visual acuity returned to baseline in only 3 of 13 eyes (23%) at the last follow-up visit.

Conclusions: Although RRD after intravitreal injection is rare, prior retinal surgery and alternate risk factors for RRD may predispose to RRD after intravitreal injection. Surgical outcomes were generally favorable, but VA outcomes were limited by the high rate of macula-off RRD and the underlying macular disease.

Keywords: Intravitreal injection; Rhegmatogenous retinal detachment.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / adverse effects*
  • Female
  • Humans
  • Intravitreal Injections / adverse effects
  • Male
  • Middle Aged
  • Retinal Detachment / chemically induced*
  • Retinal Detachment / surgery
  • Retrospective Studies
  • Visual Acuity*
  • Vitrectomy / methods


  • Angiogenesis Inhibitors