Background: We aimed to estimate the associations between aromatic amino acids (AAAs) and diabetic nephropathy (DN) in patients with type 2 diabetes (T2D).
Methods: We collected clinical and metabolomic data from 132 healthy subjects (HS group), 132 type 2 diabetes patients without diabetic nephropathy (T2D group) and 132 diabetic nephropathy patients (DN group) in tertiary hospital from May 2015 to August 2016. The odds ratio (OR) and 95% confidence interval (CI) were obtained by logistic regression.
Results: The odds ratio of tyrosine for DN increased gradually. High tyrosine was associated with an increased OR of DN (model 3, OR:0.329, 95%CI, 0.144-0.750) when comparing extreme quantiles.
Conclusion: In Chinese patients with T2D, elevated tyrosine was associated with increased risk of DN.
Keywords: Aromatic amino acids; Diabetic nephropathy; Phenylalanine; Tryptophan; Tyrosine.
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