Role of aromatic amino acids in pathogeneses of diabetic nephropathy in Chinese patients with type 2 diabetes

J Diabetes Complications. 2020 Oct;34(10):107667. doi: 10.1016/j.jdiacomp.2020.107667. Epub 2020 Jul 3.

Abstract

Background: We aimed to estimate the associations between aromatic amino acids (AAAs) and diabetic nephropathy (DN) in patients with type 2 diabetes (T2D).

Methods: We collected clinical and metabolomic data from 132 healthy subjects (HS group), 132 type 2 diabetes patients without diabetic nephropathy (T2D group) and 132 diabetic nephropathy patients (DN group) in tertiary hospital from May 2015 to August 2016. The odds ratio (OR) and 95% confidence interval (CI) were obtained by logistic regression.

Results: The odds ratio of tyrosine for DN increased gradually. High tyrosine was associated with an increased OR of DN (model 3, OR:0.329, 95%CI, 0.144-0.750) when comparing extreme quantiles.

Conclusion: In Chinese patients with T2D, elevated tyrosine was associated with increased risk of DN.

Keywords: Aromatic amino acids; Diabetic nephropathy; Phenylalanine; Tryptophan; Tyrosine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Amino Acids, Aromatic / blood*
  • Asian People*
  • Case-Control Studies
  • China
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / ethnology
  • Diabetic Nephropathies / blood*
  • Diabetic Nephropathies / ethnology
  • Diabetic Nephropathies / etiology*
  • Female
  • Humans
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio

Substances

  • Amino Acids, Aromatic