Cervicovaginal cellular angiofibroma

BMJ Case Rep. 2020 Jul 16;13(7):e235241. doi: 10.1136/bcr-2020-235241.


Cellular angiofibroma is a rare type of benign mesenchymal tumour that arises mostly in middle-aged women. It needs to be distinguished from other neoplasms and has a predilection for the vulvovaginal region. To our knowledge, this is the first case of a cervical cellular angiofibroma. A 34-year-old nulligravid woman was referred with a large mass bulging in the fornix posterior. Ultrasound scanning and MRI showed a large solid mass projecting in the pouch of Douglas. Laparoscopic surgical excision was performed. Histopathological examination showed a well-demarcated, unencapsulated tumour, consisting of short fascicles of spindle cells in-between thick-walled medium-sized vessels. On immunohistochemistry, there was strong reactivity with antibodies against CD34 and oestrogen receptor. Angiofibromas are benign mesenchymal tumours mostly occurring in middle-aged women. They can cause abnormal swelling and uterine bleeding and need to be distinguished from other (malignant) neoplasms.

Keywords: obstetrics and gynaecology; pathology.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Angiofibroma* / diagnosis
  • Angiofibroma* / pathology
  • Cervix Uteri / diagnostic imaging
  • Cervix Uteri / pathology
  • Female
  • Humans
  • Uterine Cervical Neoplasms* / diagnosis
  • Uterine Cervical Neoplasms* / pathology
  • Vagina / diagnostic imaging