Recent technical advances have dramatically increased the power and scope of structural biology. New developments in high-resolution cryo-electron microscopy, serial X-ray crystallography, and electron diffraction have been especially transformative. Here we highlight some of the latest advances and current challenges at the frontiers of atomic resolution methods for elucidating the structures and dynamical properties of macromolecules and their complexes.
Keywords: Structural biology; computational methods; electron diffraction; electron microscopy; x-ray crystallography.
Copyright: © 2020 Thompson MC et al.