Evaluation of Disease Severity and Health-Related Quality of Life in Patients with Rheumatoid Arthritis Undergoing Total Knee Arthroplasty

Alireza Rahimnia; Gholamhossein Alishiri; Mohammad E Bayatpoor; Mohammad A Hosseini; Shahriar Najafizadeh-Sari; Habib Yaribeygi; Amirhossein Sahebkar

doi:10.2174/1573397116666200717124621

Evaluation of Disease Severity and Health-Related Quality of Life in Patients with Rheumatoid Arthritis Undergoing Total Knee Arthroplasty

Curr Rheumatol Rev. 2021;17(1):88-94. doi: 10.2174/1573397116666200717124621.

Authors

Alireza Rahimnia¹, Gholamhossein Alishiri², Mohammad E Bayatpoor³, Mohammad A Hosseini⁴, Shahriar Najafizadeh-Sari³, Habib Yaribeygi⁵, Amirhossein Sahebkar⁶

Affiliations

¹ Department of Orthopedic, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
² Department of Rheumatology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
³ Student's Research Committee, Baqiyatallah University of Medical Sciences, Tehran, Iran.
⁴ Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran.
⁵ Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran.
⁶ Halal Research Center of IRI, FDA, Tehran, Iran.

PMID: 32679019
DOI: 10.2174/1573397116666200717124621

Abstract

;Background: The Total Knee Arthroplasty (TKA) is one of the most common surgical intervention in patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Previous studies suggested a significant improvement in health status after TKA surgery. But we have little data about the Iranian population undergone TKA. In the current clinical study, we evaluated postoperatively health status using reliable tools of MOS SF-36 and WOMAC in OA and RA patients undergoing TKA.

Methods: In this cohort study, patients with OA and/or RA who were candidates for TKA surgery were included. Using two reliable questionnaires, i.e., WOMAC and SF-36, the quality of life of patients was examined during a period of six months (three monthly intervals) after the surgery. All data were analyzed using IBM SPSS Statistics. Kolmogrov-Smirnov, Kendall's tau, chi-square test and K-related Non-parametric tests were used.

Results: Of the 2126 patients who underwent TKA, there were 2024 diagnosed osteoarthritis and 102 validated RA over one year. The mean ± SD of age and the average BMI were 68.0 ± 7.0 BMI 28.5 kg/m2, respectively. Regarding comorbidities and concurrent disorders, about 14% of cases were diabetic, 42% had cardiovascular diseases, 3% had respiratory diseases, and 12% involved with gastrointestinal diseases. The result of SF-36 dramatically increased during follow up. The central distributions of all domains in the SF-36 questionnaire indicated that most scores increased during the time after surgery. As a consequence, WOMAC and MOS FS-36 indicated statistically significant changes after TKA for those who are suffering from RA or OA.

Conclusion: TKA is an effective surgical process, which improves the quality of life in OA and/or RA. In addition, WOMAC and SF-36 examining tools are likely reliable tools with similar results to assess patients' quality of life after TKA surgery.

Keywords: MOS SF-36; WOMAC; arthroplasty; osteoarthritis; quality of life; rheumatoid arthritis.

MeSH terms

Aged
Arthritis, Rheumatoid / surgery*
Arthroplasty, Replacement, Knee*
Cohort Studies
Female
Humans
Male
Middle Aged
Osteoarthritis, Knee / surgery*
Quality of Life*
Self Report
Severity of Illness Index*