Pathogen Interference: Targeting Virulence Factors to Tackle Intracellular Microbes

Cell Chem Biol. 2020 Jul 16;27(7):765-767. doi: 10.1016/j.chembiol.2020.06.017.


Infections with Salmonella enterica pose a challenge for antibiotic treatment. In this issue of Cell Chemical Biology, Tsai et al. use a chemical genomics approach to identify dephostatin as an inhibitor of intracellular Salmonella virulence in vitro and in vivo by targeting the two-component systems SsrA-SsrB and PmrB-PmrA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Gene Expression Regulation, Bacterial*
  • Salmonella typhimurium / metabolism
  • Transcription Factors / metabolism
  • Virulence
  • Virulence Factors* / genetics


  • Bacterial Proteins
  • Transcription Factors
  • Virulence Factors