Necrobiosis lipoidica with rapid response to doxycycline

Pediatr Dermatol. 2020 Sep;37(5):981-982. doi: 10.1111/pde.14295. Epub 2020 Jul 18.


Necrobiosis lipoidica (NL) is a rare granulomatous disease of unknown etiology. Multiple therapies may be used with varying efficacy. We report a pediatric patient with a history of type I diabetes mellitus and NL with minimal response to an ultrapotent topical steroid, topical calcineurin inhibitor, and intralesional triamcinolone, complicated by steroid atrophy, who rapidly responded after addition of doxycycline.

Keywords: doxycycline; necrobiosis lipoidica.