Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms

Rohma Ghani; Benjamin H Mullish; Julie A K McDonald; Anan Ghazy; Horace R T Williams; Eimear T Brannigan; Siddharth Mookerjee; Giovanni Satta; Mark Gilchrist; Neill Duncan; Richard Corbett; Andrew J Innes; Jiří Pavlů; Mark R Thursz; Frances Davies; Julian R Marchesi

doi:10.1093/cid/ciaa948

Disease Prevention Not Decolonization: A Model for Fecal Microbiota Transplantation in Patients Colonized With Multidrug-resistant Organisms

Clin Infect Dis. 2021 Apr 26;72(8):1444-1447. doi: 10.1093/cid/ciaa948.

Authors

Rohma Ghani^{1

2}, Benjamin H Mullish^{1

3}, Julie A K McDonald^{1

4}, Anan Ghazy², Horace R T Williams^{1

3}, Eimear T Brannigan², Siddharth Mookerjee², Giovanni Satta², Mark Gilchrist², Neill Duncan⁵, Richard Corbett⁵, Andrew J Innes⁶, Jiří Pavlů⁶, Mark R Thursz^{1

3}, Frances Davies², Julian R Marchesi^{1

7}

Affiliations

¹ Division of Digestive Diseases, Department of Metabolism, Digestion, and Reproduction, Imperial College London, London, United Kingdom.
² Department of Infection, Imperial College Healthcare NHS Trust, London, United Kingdom.
³ Department of Gastroenterology and Hepatology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
⁴ MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom.
⁵ Department of Renal Medicine, Hammersmith Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
⁶ Centre for Haematology, Imperial College London, and Hammersmith Hospital, Imperial College London NHS Trust, London, United Kingdom.
⁷ School of Biosciences, Cardiff University, Cardiff, United Kingdom.

Abstract

Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia, and length of stay in 20 patients colonized/infected with MDRO receiving FMT (compared with pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.

Keywords: allogeneic hematopoietic cell transplantation; antimicrobial resistance; fecal microbiota transplant; gut microbiome; multidrug-resistant bacteria.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Drug Resistance, Multiple, Bacterial
Fecal Microbiota Transplantation*
Gastrointestinal Microbiome*
Humans
Intestines

Substances

Anti-Bacterial Agents

Abstract

Publication types

MeSH terms

Substances

Grants and funding